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Paper Title: EVIDENCE OF POSTTRAUMATIC COAGULOPATHY IN CASE OF THE SEVERE COMBINED THORACIC TRAUMA

ABSTRACT: Early coagulopathy associated with trauma – result of exaggerate activity during the initiation phase of coagulation. The aim of this study was to determine the diagnostic value of the coagulopathy markers for metabolic monitoring of the severe combined thoracic trauma and it’s possibly to help in outcome prediction. This retrospective study was performed on 73 male polytrauma patients from 20 to 68 years old. The prothrombin time, fibrinogen concentration and β-Naphthol test were estimated on 1-2-d, 3-4-th and 5-6-th days after trauma. The results suggest that hypocoagulation occurs early in equal extent for survivals and non-survivals. Coagulation abnormalities are the result of vital functions disturbances rather than direct tissue injury. Disseminated intravascular coagulation with a fibrinolytic phenotype is the predominant and initiative pathogenesis of trauma-related coagulopathy with maximal expression on 5-6-th day. Appearance of positive β-Naphthol test on 5-6-th day increases probable

mortality from 18.47 – 19.37% to 26.91 – 28.08%.

KEYWORDS: Severe combined thoracic trauma, Trauma-induced coagulopathy, outcome prediction, Prothrombin time,Fibrinogen, β-Naphthol test.

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